As a result of our PCAB-Accreditation for sterile compounding, urologists
nationwide work with our pharmacists and staff to compound sterile injectables
for their patients with erectile dysfunction (ED).

We compound a variety of Bi-Mix, Tri-Mix (see below), and
other sterile injectables formulated to treat this condition.
Our standard Tri-Mix
formula has been used for years by some of our nation’s leading
urologists. According to the book, Erectile Dysfunction, this injection
has been reported to be less painful and preferred by patients than
other treatments.

Most importantly, all of our injectable ED treatments are prepared in
our USP <797>, PCAB-Accredited clean room facility. Eastern States Compounding is the
first and only pharmacy in New England to earn this valuable distinction
for urological compounding.


“Triple Mix” Injection for Erectile Dysfunction

Eastern States Compounding is a Preferred Provider for TriMix Injection. Read more…

Men with erectile dysfunction (ED) who used triple therapy (papaverine/phentolamine/prostaglandin-E1)
by intracavernosal injection (ICI) and then changed to oral sildenafil
found they had a greater preference than expected for triple therapy.
Overall, the erection quality with ICI was better than that with sildenafil.

Fear of pain with intracavernosal injection (ICI) therapy may discourage
its use. Yet, findings from a Cleveland Clinic study show that in the
majority of ED patients, discomfort is minimal. (2)

Treatment with self-injections
of vasoactive drugs in men with diabetes (both type 1 and type 2) and
severe ED is a safe and effective alternative in the long term. The key
is adjustment of the therapeutic method and dosage to optimal levels
for satisfactory erections. (3)

Early intracavernosal injections following
radical prostatectomy facilitated early sexual intercourse, patient satisfaction
and potentially earlier return of natural erections, according to a study
from the Glickman Urological Institute, Cleveland Clinic Foundation.
Early combination therapy with sildenafil allowed a lower dose of intracavernous
injections, minimizing the penile discomfort. (4)

A higher percentage of positive response in patients
with erectile dysfunction was achieved with the trimix modality. Choice
of more potent ICI regimens can improve efficacy. (5)

  1. BJU Int. 2003 Aug;92(3):277-80.
    Preference for oral sildenafil or intracavernosal injection in patients
    with erectile dysfunction already using intracavernosal injection for > 1
    Click here to access the PubMed abstract of this article.
  2. J Sex Med.
    2005 May;2(3):428-31.
    Use of a visual analog scale to assess pain of injection with intracavernous
    injection therapy.
    Click here to access the PubMed abstract of this article.
  3. Asian J Androl. 2006 Mar;8(2):219-24.
    Long-term treatment with intracavernosal injections in diabetic men
    with erectile dysfunction.
    Click here to access the PubMed abstract of this article.
  4. Int J Impot
    Res. 2006 Sep-Oct;18(5):446-51. Epub 2006 Feb 16.
    Early combination therapy: intracavernosal injections and sildenafil
    following radical prostatectomy increases sexual activity and the return
    of natural erections.
    Click here to access the PubMed abstract of this article.
  5. Arch Esp Urol. 2001 May;54(4):355-9.
    [Response to intracavernous administration of 3 different drugs in
    the same group of patients with erectile dysfunction] Click here to access the PubMed abstract of this article.

Resources – PubMed U.S. National
Library of Medicine National Institutes of Health. Eastern States Compounding is not responsible
for content on third-party websites.