Urological Compounding

Sterile Compounding for Urologists

Urologists nationwide work with our pharmacists and staff to compound sterile injectables for their patients with erectile dysfunction (ED).

We compound a variety of Bi-Mix, Tri-Mix (see below), and
other sterile injectables formulated to treat this condition. 
Our standard Tri-Mix formula has been used for years by some of our nation’s leading urologists.

According to the book, Erectile Dysfunction, this injection has been reported to be less painful and preferred by patients than other treatments.

“Triple Mix” Injection for Erectile Dysfunction

Eastern States Compounding is a Preferred Provider for TriMix Injection.
Related Research

Men with erectile dysfunction (ED) who used triple therapy (papaverine/phentolamine/prostaglandin-E1) by intracavernosal injection (ICI) and then changed to oral sildenafil found they had a greater preference than expected for triple therapy. Overall, the erection quality with ICI was better than that with sildenafil.(1)

Fear of pain with intracavernosal injection (ICI) therapy may discourage its use. Yet, findings from a Cleveland Clinic study show that in the majority of ED patients, discomfort is minimal. (2)

Treatment with self-injections of vasoactive drugs in men with diabetes (both type 1 and type 2) and severe ED is a safe and effective alternative in the long term. The key is adjustment of the therapeutic method and dosage to optimal levels for satisfactory erections. (3)

Early intracavernosal injections following radical prostatectomy facilitated early sexual intercourse, patient satisfaction and potentially earlier return of natural erections, according to a study from the Glickman Urological Institute, Cleveland Clinic Foundation.

Early combination therapy with sildenafil allowed a lower dose of intracavernous injections, minimizing the penile discomfort. (4)

A higher percentage of positive response in patients with erectile dysfunction was achieved with the trimix modality. Choice of more potent ICI regimens can improve efficacy. (5)


  1. BJU Int. 2003 Aug;92(3):277-80.
    Preference for oral sildenafil or intracavernosal injection in patients
    with erectile dysfunction already using intracavernosal injection for > 1
    Click here to access the PubMed abstract of this article.
  2. J Sex Med.
    2005 May;2(3):428-31.
    Use of a visual analog scale to assess pain of injection with intracavernous
    injection therapy.
    Click here to access the PubMed abstract of this article.
  3. Asian J Androl. 2006 Mar;8(2):219-24.
    Long-term treatment with intracavernosal injections in diabetic men
    with erectile dysfunction.
    Click here to access the PubMed abstract of this article.
  4. Int J Impot
    Res. 2006 Sep-Oct;18(5):446-51. Epub 2006 Feb 16.
    Early combination therapy: intracavernosal injections and sildenafil
    following radical prostatectomy increases sexual activity and the return
    of natural erections.
    Click here to access the PubMed abstract of this article.
  5. Arch Esp Urol. 2001 May;54(4):355-9.
    [Response to intracavernous administration of 3 different drugs in
    the same group of patients with erectile dysfunction] Click here to access the PubMed abstract of this article.
  6. http://www.ncbi.nlm.nih.gov/pubmed – PubMed U.S. National Library of Medicine National Institutes of Health. Eastern States Compounding is not responsible for content on third-party websites.

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Eastern States Compounding works closely with you, whether you’re a patient looking for more effective medication, or a provider looking for the best solutions for your patients.

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