T4/T3 Capsules for Thyroid Issues

The statements below have not been evaluated by the FDA.

What are T4/T3 Capsules?

Thyroid stimulating hormones (TSH) helps your thyroid glands release T4 and T3, both that are in T4/T3 capsules. T4 handles your mood, metabolism, and body temperature. T3 is also made in the thyroid gland, as well as in other tissues and focuses on your digestive and metabolic function, along with bone health.

Those suffering from hypothyroidism may benefit from T4/T3 capsules. Unlike hyperthyroidism, which is characterized by high or surging thyroid levels, hypothyroidism results from low thyroid levels. The amount of stimulation that T4 and T3 inside thyroid capsules give thyroid levels in patients a boost.

Hypothyroidism signs and symptoms may include:

  • Fatigue
  • Increased sensitivity to cold
  • Constipation
  • Dry skin
  • Weight gain
  • Puffy face
  • Hoarseness
  • Muscle weakness
  • Elevated blood cholesterol level
  • Muscle aches, tenderness and stiffness
  • Pain, stiffness or swelling in your joints
  • Heavier than normal or irregular menstrual periods
  • Thinning hair
  • Slowed heart rate
  • Depression
  • Impaired memory
  • Enlarged thyroid gland (goiter)

Source: Mayo Clinic

Frequently Asked Questions

Consult with your provider if you are experiencing any of the symptoms mentioned previously. If there is cause for concern, or you are simply due for assessing your overall health, your practitioner can prescribe a hormone profile saliva test, where different kits test different hormone levels.

Step-by-Step Guide for At-Home Saliva Testing »

Please contact Eastern States Compounding Pharmacy and our experts will be happy to guide you through the journey to optimal health. We work with providers and their patients to educate and provide customized treatments for thyroid conditions, among other health challenges.

Ask a Pharmacist »

T3/T4 Requires a Prescription from your Doctor. 

Dosage Forms

If you need another form due to inability to take capsules, consult expert pharmacists at Eastern States Compounding for alternative forms.

Related Links: Thyroid Hormone Treatment | American Thyroid Association

What are T3, T4, and TSH? – Understanding your thyroid test results (endocrineweb.com)


Related Reading

Wiersinga, W.M. T4 + T3 Combination Therapy: Any Progress?

Endocrine 66. 2019:70–78. https://link.springer.com/article/10.1007/s12020-019-02052-2. Accessed February 2, 2022. 


Guidelines on T4 + T3 combination therapy were published in 2012. This review investigates whether the issue is better understood 7 years later. Dissatisfaction with the outcome of T4 monotherapy remains high. Persistent symptoms consist mostly of fatigue, weight gain, problems with memory and thinking and mood disturbances. T4 monotherapy is associated with low serum T3 levels, which often require TSH-suppressive doses of L-T4 for normalization. 

Negro R, Attanasio R, Nagy E, et al. Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: the 2019 Italian Survey.

Eur Thyroid J. 2020;9:25-31. https://pubmed.ncbi.nlm.nih.gov/33774809/.
Accessed February 2, 2022.


Purpose: The standard treatment of hypothyroidism is levothyroxine (LT4), which is available as tablets or soft-gel capsules in Denmark. This study aimed to investigate Danish endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid patients.

Methods: An e-mail with an invitation to participate in an online survey investigating practices about substitution with thyroid hormones was sent to all members of the Danish Endocrine Society (DES).

Mohamed K M Shakir, Daniel I Brooks, Elizabeth A McAninch, et al. Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.

The Journal of Clinical Endocrinology & Metabolism. 2020;106(11):4400–e4413.
Accessed February 2, 2022. 


Introduction: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) did not detect consistent superiority of either treatment. Here, we investigated these therapies, focusing on the whole group of LT4-treated hypothyroid patients, while also exploring the most symptomatic patients.

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Please contact us by filling out the form below, or calling us at (800) 964-0094 Ext. 0 or by email info@easternstatesrx.com if you have questions or need information about Eastern States Compounding Pharmacy.

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